Production in Pichia pastoris
Expertise with a range of P. pastoris expression systems
Pichia pastoris (now Komagataella phaffii) is a highly competitive host for the production of recombinant proteins.
This FDA-approved system shows a high secretion capacity of heterologous proteins and can be grown to high cell densities, making it one of the most cost-efficient systems for protein production.
Our team has successfully produced a diversity of proteins (enzymes, antibody fragments, antigens…) in different P. pastoris systems, with inducible or constitutive expression.
Customised services for efficient P. pastoris protein expression
GTP Bioways offers customised services that span the entire range from gene or sequence to highly productive expression strains and processes:
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- Generation of P. pastoris strain, including expression vector design & construction and when relevant, screening of strains, promoters and signal sequences
- Screening of up to several thousand clones to identify high producers
- Development of fed-batch fermentations
- Development/optimisation of the purification process
GTP Bioways has expertise with other expression systems
We excel at protein production with all prominent industrial microbial, mammalian and insect cell expression systems such as P. pastoris, CHO, HEK and Sf9.
E. coli
We have successfully developed protein expression processes in E. coli with a diversity of strategies.
Mammalian cells
We offer both transient and stable expression of proteins and antibodies in CHO and HEK cells.
Insect cells
We are experts in the production of target, reagent and vaccine proteins using insect cells.
Are you looking for experts to produce your challenging protein in P. pastoris?
Connect with our team and we will get back to you shortly.
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